ALPERS-HUTTENLOCHER SYNDROME

Alpers-Huttenlocher Apparel syndrome is a rare mitochondrial disease connected with mutations in the mitochondrial DNA replicase, polymerase gamma (POLG).The reduction of the activity within mitochondrial enzymes is connected with the reduction of replications level within the mitochondrial DNA.The disease manifests itself once the replications lev

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Sleep patterns and the risk for ADHD: a review

Jamie FULL CIRCLE LEAVE IN TREATMENT Cassoff,1,2 Sabrina T Wiebe,1,2 Reut Gruber1,21Attention, Behavior and Sleep Lab, Douglas Mental Health University Institute, Montréal, Quebec, Canada; 2McGill University, Montréal, Quebec, CanadaAbstract: Attention-deficit/hyperactivity disorder (ADHD) is often associated with comorbid sle

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Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review

Prenatal immune challenge (PIC) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism.Based on this, the goal of this article was to review the main contributions of PIC models, especially the one using the viral-mimetic particle polyriboinosinic-polyri

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